Welcome to the Knoxville Chamber’s website. We were named the 2011 National Chamber of the Year by the American Chamber of Commerce Executives because of the unique and progressive programs we offer businesses in Knoxville, Knox County, and throughout the Innovation Valley. As the largest chamber of commerce in East Tennessee, we represent over 2,000 businesses of all sizes and at all stages of maturity. Whether we are helping existing businesses grow, recruiting new companies to the region, striving to establish a world-class workforce, or advocating for business-friendly government, we are working to fulfill our mission of Driving Regional Economic Prosperity.